Sugar-based products: crystallised fruits and vegetables, candied fruits, jam and. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. paste, fruit and chilli paste, garlic paste, etc) sauces and chutney. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Home Home Podcasts Podcasts Library Cancel. Stream ad-free with Amazon Music Unlimited on mobile, desktop, and tablet.

Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Listen to your favorite songs from Jam On It by Newcleus Now.

In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Acts both as a regulator of telomere function and as a transcription regulator.

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